/* msc-exosome.com — DRAFT SITE — not for live deployment */
/*
  Visual refresh notes: typography/color/spacing loosely informed by
  contemporary longevity/health-education sites (clean modern sans-serif,
  deep navy + clinical teal, generous whitespace) — no text, imagery,
  logos, or copy taken from any reference site. Content/structure unchanged.

  Polish pass: fixed nav/link contrast to WCAG AA, replaced translucent
  blurred header with a solid header (removes scroll-compositing ghosting),
  added mobile breakpoints, zebra-striped + scroll-safe tables, card hover
  accent bars, a calmer footer treatment, and a lightweight brand favicon.
*/

:root {
  --ink: #132a3a;
  --ink-soft: #57697c;
  --paper: #fbfaf7;
  --paper-alt: #eef2f3;
  --line: #dde4e4;
  --accent: #0e7c72;       /* use for borders, backgrounds, box-shadows */
  --accent-text: #0c6f66;  /* darkened for AA-safe text/link contrast */
  --accent-soft: #e1f1ee;
  --warn-bg: #fdeeec;
  --warn-border: #c1483c;
  --warn-text: #7d2c22;
  --flag-bg: #fdf3df;
  --flag-border: #b8860b;
  --flag-text: #6b4e00;
  --link: var(--accent-text);
  --max-w: 880px;
  --font-heading: "Sora", -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
  --font-body: "Inter", -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
}

* { box-sizing: border-box; }

html { scroll-behavior: smooth; }

body {
  margin: 0;
  font-family: var(--font-body);
  color: var(--ink);
  background: var(--paper);
  line-height: 1.68;
  -webkit-font-smoothing: antialiased;
}

.draft-banner {
  background: var(--ink);
  color: #fff;
  text-align: center;
  font-family: var(--font-body);
  font-size: 0.8rem;
  letter-spacing: 0.06em;
  padding: 9px 12px;
  text-transform: uppercase;
}

header.site-header {
  border-bottom: 1px solid var(--line);
  background: var(--paper);
  box-shadow: 0 1px 3px rgba(19, 42, 58, 0.05);
  position: sticky;
  top: 0;
  z-index: 20;
}

.header-inner {
  max-width: 1100px;
  margin: 0 auto;
  display: flex;
  align-items: center;
  justify-content: space-between;
  padding: 20px 24px;
  font-family: var(--font-body);
}

.brand {
  font-family: var(--font-heading);
  font-weight: 700;
  font-size: 1.2rem;
  color: var(--ink);
  text-decoration: none;
  letter-spacing: -0.01em;
}
.brand span { color: var(--accent-text); }

nav.primary-nav {
  display: flex;
  flex-wrap: wrap;
  gap: 4px 2px;
  max-width: 1100px;
  margin: 0 auto;
  padding: 0 24px 16px;
  font-family: var(--font-body);
  font-size: 0.85rem;
}
nav.primary-nav a {
  color: var(--ink-soft);
  text-decoration: none;
  padding: 7px 12px;
  border-radius: 20px;
  font-weight: 500;
  transition: background 0.15s ease, color 0.15s ease;
}
nav.primary-nav a:hover, nav.primary-nav a.active {
  background: var(--accent-soft);
  color: var(--accent-text);
}
nav.primary-nav a.active { font-weight: 600; }

main {
  max-width: var(--max-w);
  margin: 0 auto;
  padding: 48px 24px 88px;
}

.hero {
  max-width: 1100px;
  margin: 0 auto;
  padding: 64px 24px 44px;
  text-align: left;
}
.hero h1 {
  font-family: var(--font-heading);
  font-size: 2.25rem;
  line-height: 1.22;
  max-width: 760px;
  margin: 0 0 18px;
  letter-spacing: -0.01em;
}
.hero p.lede {
  font-size: 1.15rem;
  color: var(--ink-soft);
  max-width: 680px;
}

h1 {
  font-family: var(--font-heading);
  font-weight: 700;
  font-size: 1.95rem;
  margin-top: 0;
  line-height: 1.28;
  letter-spacing: -0.01em;
}
h2 {
  font-family: var(--font-heading);
  font-weight: 600;
  font-size: 1.38rem;
  margin-top: 2.6em;
  padding-top: 1em;
  border-top: 2px solid var(--accent-soft);
  letter-spacing: -0.005em;
}
h3 {
  font-family: var(--font-heading);
  font-weight: 600;
  font-size: 1.1rem;
  margin-top: 1.9em;
  color: var(--accent-text);
}
p { margin: 1.05em 0; }
ul, ol { padding-left: 1.4em; }
li { margin: 0.45em 0; }

a { color: var(--link); }
a:hover { text-decoration-thickness: 2px; }

.section-eyebrow {
  font-family: var(--font-body);
  text-transform: uppercase;
  letter-spacing: 0.1em;
  font-size: 0.74rem;
  color: var(--accent-text);
  font-weight: 700;
  margin-bottom: 8px;
}

.disclaimer-box {
  background: var(--warn-bg);
  border: 1px solid var(--warn-border);
  color: var(--warn-text);
  border-radius: 12px;
  padding: 18px 20px;
  font-family: var(--font-body);
  font-size: 0.92rem;
  margin: 26px 0;
}
.disclaimer-box strong { color: var(--warn-text); }
.disclaimer-box.compact { padding: 13px 16px; font-size: 0.85rem; }

/* Calmer treatment for the boilerplate legal block repeated in the footer —
   keeps the in-content warning boxes (above) visually reserved for
   page-specific cautions instead of every page reading "alarmed" top to bottom. */
.disclaimer-box.footer {
  background: #fff;
  border: 1px solid var(--line);
  color: var(--ink-soft);
}
.disclaimer-box.footer strong { color: var(--ink); }

.flag-box {
  background: var(--flag-bg);
  border: 1px solid var(--flag-border);
  color: var(--flag-text);
  border-radius: 12px;
  padding: 16px 18px;
  font-family: var(--font-body);
  font-size: 0.88rem;
  margin: 20px 0;
}
.flag-box strong { color: var(--flag-text); }

.info-box {
  background: var(--paper-alt);
  border: 1px solid var(--line);
  border-radius: 12px;
  padding: 18px 20px;
  margin: 20px 0;
  font-family: var(--font-body);
  font-size: 0.92rem;
}

.table-wrap {
  overflow-x: auto;
  -webkit-overflow-scrolling: touch;
  margin: 1.5em 0;
  border: 1px solid var(--line);
  border-radius: 12px;
}
table {
  width: 100%;
  min-width: 480px;
  border-collapse: collapse;
  margin: 0;
  font-family: var(--font-body);
  font-size: 0.88rem;
}
th, td {
  border: 1px solid var(--line);
  padding: 9px 11px;
  text-align: left;
  vertical-align: top;
}
th { background: var(--paper-alt); font-weight: 700; font-family: var(--font-heading); }
table tr:nth-child(even) td { background: rgba(19, 42, 58, 0.025); }
.table-wrap table { border: none; }
.table-wrap th:first-child, .table-wrap td:first-child { border-left: none; }
.table-wrap th:last-child, .table-wrap td:last-child { border-right: none; }
.table-wrap tr:first-child th { border-top: none; }

.card-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(240px, 1fr));
  gap: 16px;
  margin: 26px 0;
}
.card {
  position: relative;
  overflow: hidden;
  border: 1px solid var(--line);
  border-radius: 14px;
  padding: 24px 22px 22px;
  background: var(--paper-alt);
  font-family: var(--font-body);
  transition: box-shadow 0.15s ease, border-color 0.15s ease, transform 0.15s ease;
}
.card::before {
  content: "";
  position: absolute;
  top: 0; left: 0; right: 0;
  height: 3px;
  background: var(--accent);
  transform: scaleX(0);
  transform-origin: left;
  transition: transform 0.18s ease;
}
.card:hover { border-color: var(--accent); box-shadow: 0 8px 22px rgba(14, 124, 114, 0.12); transform: translateY(-2px); }
.card:hover::before { transform: scaleX(1); }
.card h3 { margin-top: 0; font-size: 1.02rem; }
.card p { font-size: 0.88rem; color: var(--ink-soft); margin: 0.5em 0 14px; }
.card a {
  display: inline-flex;
  align-items: center;
  gap: 5px;
  font-size: 0.85rem;
  font-weight: 600;
  text-decoration: none;
}
.card a:hover { text-decoration: underline; text-underline-offset: 3px; }

.card-num {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  width: 22px;
  height: 22px;
  margin-right: 8px;
  border-radius: 50%;
  background: var(--accent-soft);
  color: var(--accent-text);
  font-family: var(--font-heading);
  font-size: 0.75rem;
  font-weight: 700;
  vertical-align: middle;
}

.toc {
  font-family: var(--font-body);
  background: var(--paper-alt);
  border: 1px solid var(--line);
  border-radius: 12px;
  padding: 18px 22px;
  font-size: 0.9rem;
}
.toc ol { margin: 0.5em 0 0; padding-left: 1.2em; }

.sources {
  font-family: var(--font-body);
  font-size: 0.84rem;
  color: var(--ink-soft);
}
.sources h2 { border-top: 2px solid var(--accent-soft); }
.sources ol { padding-left: 1.3em; }
.sources li { margin: 0.6em 0; }

.verify-tag {
  display: inline-block;
  background: var(--flag-bg);
  border: 1px solid var(--flag-border);
  color: var(--flag-text);
  font-size: 0.72rem;
  font-family: var(--font-body);
  font-weight: 700;
  text-transform: uppercase;
  letter-spacing: 0.04em;
  padding: 2px 8px;
  border-radius: 20px;
  margin-left: 6px;
}

.study-list {
  font-family: var(--font-body);
  font-size: 0.86rem;
  list-style: none;
  padding-left: 0;
}
.study-list li {
  border-bottom: 1px solid var(--line);
  padding: 12px 0;
}
.study-list .study-meta { color: var(--ink-soft); font-size: 0.8rem; }

footer.site-footer {
  border-top: 1px solid var(--line);
  background: var(--paper-alt);
  margin-top: 64px;
  padding: 40px 24px 54px;
  font-family: var(--font-body);
}
.footer-inner { max-width: 1100px; margin: 0 auto; }
.footer-inner .disclaimer-box { font-size: 0.82rem; }
.footer-nav-title {
  display: block;
  text-transform: uppercase;
  letter-spacing: 0.08em;
  font-size: 0.7rem;
  font-weight: 700;
  color: var(--ink-soft);
  margin: 24px 0 10px;
}
.footer-links { display: flex; flex-wrap: wrap; gap: 6px 18px; font-size: 0.82rem; }
.footer-links a { color: var(--ink-soft); text-decoration: none; }
.footer-links a:hover { color: var(--accent-text); text-decoration: underline; }
.footer-note { margin-top: 20px; padding-top: 16px; border-top: 1px solid var(--line); font-size: 0.76rem; color: var(--ink-soft); }

blockquote {
  border-left: 3px solid var(--accent);
  margin: 1.2em 0;
  padding: 0.4em 0 0.4em 1.1em;
  color: var(--ink-soft);
  font-style: italic;
}

code { font-family: "SFMono-Regular", Consolas, monospace; font-size: 0.85em; background: var(--paper-alt); padding: 1px 5px; border-radius: 4px; }

/* ---------- Responsive ---------- */
@media (max-width: 720px) {
  .draft-banner { font-size: 0.68rem; letter-spacing: 0.03em; padding: 8px 10px; }
  .header-inner { padding: 16px 18px; }
  .brand { font-size: 1.08rem; }
  nav.primary-nav { padding: 0 14px 14px; gap: 3px 2px; font-size: 0.8rem; }
  nav.primary-nav a { padding: 6px 10px; }
  main { padding: 34px 18px 64px; }
  .hero { padding: 40px 18px 30px; }
  .hero h1 { font-size: 1.7rem; }
  .hero p.lede { font-size: 1.02rem; }
  h1 { font-size: 1.55rem; }
  h2 { font-size: 1.2rem; margin-top: 2.1em; }
  h3 { font-size: 1.02rem; }
  table { font-size: 0.82rem; }
  th, td { padding: 8px 9px; }
  .footer-links { gap: 5px 14px; }
  footer.site-footer { padding: 32px 18px 40px; }
}

@media (max-width: 420px) {
  .draft-banner { font-size: 0.62rem; }
  main { padding: 28px 14px 56px; }
  .hero { padding: 32px 14px 24px; }
  .hero h1, h1 { font-size: 1.4rem; }
}